Virology

Measles Virus- Laboratory Diagnosis, Treatment, Prevention and Control

Measles Virus- Lab Diagnosis, Treatment, Prevention and Control

Laboratory diagnosis of Measles Virus Demonstration of clinical form i.e koplik’s spots. Microscopy – demonstration of multinucleated giant cells measuring 100n min diameter obtained from nasopharyngeal secretion and stained with Giemsa stain. Virus isolation Measles virus can be isolated from a variety of sources, e.g. throat or conjunctival washings, sputum, urinary sediment cells and lymphocytes. Primary … Read moreMeasles Virus- Laboratory Diagnosis, Treatment, Prevention and Control

Structure and Genome of Human Cytomegalo Virus

Structure and Genome of Human Cytomegalo Virus

Structure of Human Cytomegalo Virus Cytomegalovirus (CMV) is a member of the herpes virus family which fall under the beta herpes subfamily. CMV is spherical in shape with icosahedral symmetry. Figure: Structure of Human Cytomegalo Virus, Source: Dr. Marko Reschke, Marburg, Germany The icosahedral protein capsid with average diameter 100 nm consists of 162 hollow hexagonal … Read moreStructure and Genome of Human Cytomegalo Virus

Structure and Genome of Measles Virus

Structure of Measles Virus Measles virus is the prototypic member of the Morbillivirus genus of the family Paramyxoviridae. Measles virus is a spherical with a diameter ranging from 120 to 1000 nm and has two major structural components: one is the helical ribonucleoprotein (RNP) core formed by the association of the nucleoprotein (N), phosphoprotein (P) and large … Read moreStructure and Genome of Measles Virus

Lassa Virus

Lassa Virus

Structure of Lassa Virus The virus is a single-stranded RNA virus belonging to the virus family Arenaviridae. Figure: Structure of Lassa Virus, Source: Swiss Institute of Bioinformatics The virion is spherical particles with an average diameter of 90–110 nm. Lassa virus is a single-stranded RNA virus that is enveloped in lipid with glycoprotein spikes protruding from … Read moreLassa Virus

Crimean-Congo Hemorrhagic Fever Virus

Crimean-Congo Hemorrhagic Fever Virus

Structure of Crimean-Congo Hemorrhagic Fever Virus Crimean Congo hemorrhagic fever virus falls under the family Bunyaviridae and genus Nairo virus. They are spherical particles 90 to 120 nm in diameter with 5-10 nm projections visible on the surface. Figure: Crimean‐Congo hemorrhagic fever virus structure. Source: DOI: 10.3892/br.2015.545 They are enveloped virus which comprises of two glycoproteins (G1 … Read moreCrimean-Congo Hemorrhagic Fever Virus

Human Astrovirus

Human Astrovirus

Structure of Human Astrovirus Human astrovirus falls under Astroviridae and genus Mamastrovirus. The particles are round in shape, 28 nm in diameter with a smooth margin and display a five or six pointed star motif on their surface.The term astrovirus (Greek: astron- star) was coined to refer this feature. They are non-enveloped, spherical, capsid of about … Read moreHuman Astrovirus

How viruses cause disease?

How viruses cause disease

Viruses gain access to the host through skin and mucous membranes, and via the respiratory, gastrointestinal, and genital tracts. Their virulence or lack of it may be determined by very small mutations in the genome. Viral infection of cells may result in lysis, fusion and syncytium formation, the appearance of inclusion bodies, or, in some … Read moreHow viruses cause disease?

Viruses- Structure, Replication and Diagnosis

Viruses- Structure, Replication and Diagnosis

Structure of Virus LIPID ENVELOPE Usually formed from a lipid bilayer taken from their host, into which the virus inserts its own glycoproteins (enveloped virus). Not all viruses have envelopes (naked virus). Viruses without envelopes are less prone to damage by external factors, such as pH, than those with envelopes. The lipid envelope also determines … Read moreViruses- Structure, Replication and Diagnosis

Coltivirus

Coltivirus

Structure of Coltivirus Coltivirusparticles are 60–80 nm in diameter having two concentric capsid shells with a core that is about 50 nm in diameter. They have a relatively smooth surface capsomeric structure and icosahedral symmetry. Non enveloped, icosahedral virion with a triple capsid structure, about 60-80 nm in diameter. Each virion contains a full‐length copy of 12 segments … Read moreColtivirus

Coronavirus

Coronavirus

Structure of Coronavirus Coronaviruses falls in the virus family Coronaviridae, order Nidovirales. Coronaviruses are enveloped, 120 to 160 nm particles that contain an unsegmented genome of single-stranded positive sense RNA (27–32 kb). The large, plus-stranded RNA genome associates with the N protein to form a helical nucleocapsid. The helical nucleocapsid is 9–11 nm in diameter. There … Read moreCoronavirus