In Silico drug designing and role of bioinformatics

drug designing

“In Silico” is an expression used to mean “performed on computer or via computer simulation.”  In Silico drug designing is thus the identification of the drug target molecule by employing bioinformatics tools. The inventive process of finding new medications based on the knowledge of … Read more

Methicillin Resistant Staphylococcus aureus (MRSA)

Methicillin Resistant Staphylococcus aureus (MRSA)

MRSA is mediated by the mecA gene; which is chromosomally coded. It alters penicillin-binding protein (PBP) present on S. aureus cell membrane to PBP-2a: PBP is an essential protein needed for the cell wall synthesis of bacteria. β lactam drugs … Read more

Beta-Lactamase and Ambler classification

Beta-Lactamase and Ambler classification

β-lactamase enzymes are capable of hydrolysing the β-lactam rings (the active site) of β-lactam antibiotics; thereby deactivating their antibacterial properties. It is observed in both gram-positive and gram-negative bacteria. They are plasmid coded, and transferred from one bacterium to other … Read more

Beta (β) Lactamase Test- Objectives, Principle, Procedure, Results

Result Interpretation of Beta (β)-Lactamase Test

Objective of Beta (β)-Lactamase Test To detect the enzyme beta-lactamase, which confers penicillin resistance to various bacterial organisms. Principle of Beta (β)-Lactamase Test Various bacteria produce a class of enzymes called beta-lactamases, which may be mediated by genes on plasmids or chromosomes. Production of … Read more