Secondary Databases

Secondary Databases

A biological database is a large, organized body of persistent data, usually associated with computerized software designed to update, query, and retrieve components of the data stored within the system. The chief objective of the development of a database is to organize … Read more

Nucleotide sequences database

Nucleotide sequences database

As biology has increasingly turned into a data-rich science, the need for storing and communicating large datasets has grown tremendously. The obvious examples are the nucleotide sequences, the protein sequences, and the 3D structural data produced by X-ray crystallography and … Read more

Genomics

Genomics

Genome refers to the complete set of genes or genetic material present in a cell or organism while genomics is the study of genomes. Genomic studies are characterized by simultaneous analysis of a large number of genes using automated data … Read more

How to construct a Phylogenetic tree ?

How to construct a Phylogenetic tree

A phylogenetic tree is a visual representation of the relationship between different organisms, showing the path through evolutionary time from a common ancestor to different descendants. Similarities and divergence among related biological sequences revealed by sequence alignment often have to … Read more

FASTA and BLAST

BLAST

The number of DNA and protein sequences in public databases is very large. Searching a database involves aligning the query sequence to each sequence in the database, to find significant local alignment. BLAST and FASTA are two similarity searching programs … Read more

The Human Genome Project

The Human Genome Project

The start of the human genome project in the late 1980s provided a major boost for the development of bioinformatics. The Human Genome Project (HGP) was the international, collaborative research program whose goal was the complete mapping and understanding of … Read more

Biological Databases- Types and Importance

Biological Databases- Types and Importance

One of the hallmarks of modern genomic research is the generation of enormous amounts of raw sequence data. As the volume of genomic data grows, sophisticated computational methodologies are required to manage the data deluge. Thus, the very first challenge … Read more

Bioinformatics- Introduction and Applications

Bioinformatics- Introduction and Applications

With a large number of prokaryotic and eukaryotic genomes completely sequenced and more forthcoming, access to the genomic information and synthesizing it for the discovery of new knowledge have become central themes of modern biological research. Mining the genomic information … Read more