Secondary Databases

Secondary Databases

Secondary Databases A biological database is a large, organized body of persistent data, usually associated with computerized software designed to update, query, and retrieve components of the data stored within the system. The chief objective of the development of a database is to organize data in a set of structured records to enable easy retrieval of information. … Read moreSecondary Databases

Homology Modeling- Working, Steps, and Uses

Homology Modeling- Working, Steps, and Uses

Homology Modeling- Working, Steps, and Uses Homology modeling is also known as comparative modeling predicts protein structures based on sequence homology with known structures. It is based on the principle that “if two proteins share a high enough sequence similarity, they are likely to have very similar three-dimensional structures.” It hence relies on the identification … Read moreHomology Modeling- Working, Steps, and Uses

Nucleotide sequences database

Nucleotide sequences database

Nucleotide sequences database As biology has increasingly turned into a data-rich science, the need for storing and communicating large datasets has grown tremendously. The obvious examples are the nucleotide sequences, the protein sequences, and the 3D structural data produced by X-ray crystallography and macromolecular NMR. The biological information of nucleic acids is available as sequences … Read moreNucleotide sequences database

Genomics

Genomics

Genomics Genome refers to the complete set of genes or genetic material present in a cell or organism while genomics is the study of genomes. Genomic studies are characterized by simultaneous analysis of a large number of genes using automated data gathering tools. Genomics is a discipline in genetics that applies recombinant DNA, DNA sequencing … Read moreGenomics

Difference Between Genomics and Proteomics

Difference Between Genomics and Proteomics

Difference Between Genomics and Proteomics Genomics and proteomics are closely-related fields. The main difference between genomics and proteomics is that genomics is the study of the entire set of genes in the genome of a cell whereas proteomics is the study of the entire set of proteins produced by the cell. S.N. Character Genomics Proteomics 1.       Definition Genomics is … Read moreDifference Between Genomics and Proteomics

Protein Databases- Types and Importance

Protein Databases- Types and Importance

Protein Databases- Types and Importance As biology has increasingly turned into a data-rich science, the need for storing and communicating large datasets has grown tremendously. The obvious examples are the nucleotide sequences, the protein sequences, and the 3D structural data produced by X-ray crystallography and macromolecular NMR. The biological information of proteins is available as sequences … Read moreProtein Databases- Types and Importance

In Silico drug designing and role of bioinformatics

drug designing

In Silico drug designing and role of bioinformatics “In Silico” is an expression used to mean “performed on computer or via computer simulation.”  In Silico drug designing is thus the identification of the drug target molecule by employing bioinformatics tools. The inventive process of finding new medications based on the knowledge of a biological target is called as drug designing. … Read moreIn Silico drug designing and role of bioinformatics

How to construct a Phylogenetic tree ?

How to construct a Phylogenetic tree

How to construct a Phylogenetic tree ? A phylogenetic tree is a visual representation of the relationship between different organisms, showing the path through evolutionary time from a common ancestor to different descendants. Similarities and divergence among related biological sequences revealed by sequence alignment often have to be rationalized and visualized in the context of phylogenetic … Read moreHow to construct a Phylogenetic tree ?

FASTA and BLAST

BLAST

FASTA and BLAST The number of DNA and protein sequences in public databases is very large. Searching a database involves aligning the query sequence to each sequence in the database, to find significant local alignment. BLAST and FASTA are two similarity searching programs that identify homologous DNA sequences and proteins based on the excess sequence … Read moreFASTA and BLAST

Gene Prediction- Importance and Methods

Gene Prediction

Gene Prediction- Importance and Methods Gene prediction by computational methods for finding the location of protein coding regions is one of the essential issues in bioinformatics. Gene prediction basically means locating genes along a genome. Also called gene finding, it refers to the process of identifying the regions of genomic DNA that encode genes. This includes protein … Read moreGene Prediction- Importance and Methods