Genomics vs Proteomics- Definition and 10 Major Differences

Difference Between Genomics and Proteomics

Genomics and Proteomics Genomics and proteomics are closely-related fields. The main difference between genomics and proteomics is that genomics is the study of the entire set of genes in the genome of a cell whereas proteomics is the study of the entire set of proteins produced by the cell. Key Differences (Genomics vs Proteomics) S.N. Character Genomics Proteomics 1.       Definition Genomics is the study of genomes which refers to the complete set of genes or genetic material present in a cell or organism. Proteomics … Read more

Secondary Databases

Secondary Databases

A biological database is a large, organized body of persistent data, usually associated with computerized software designed to update, query, and retrieve components of the data stored within the system. The chief objective of the development of a database is to organize data in a set of structured records to enable easy retrieval of information. Based on their contents, biological databases can be either primary database or secondary databases. Among the two, secondary databases have become a biologist’s reference library over the … Read more

Homology Modeling- Working, Steps, and Uses

Homology Modeling- Working, Steps, and Uses

Homology modeling is also known as comparative modeling predicts protein structures based on sequence homology with known structures. It is based on the principle that “if two proteins share a high enough sequence similarity, they are likely to have very similar three-dimensional structures.” It hence relies on the identification of one or more known protein structures likely to resemble the structure of the query sequence, and on the production of an alignment that maps residues in the query sequence to residues in … Read more

Nucleotide sequences database

Nucleotide sequences database

As biology has increasingly turned into a data-rich science, the need for storing and communicating large datasets has grown tremendously. The obvious examples are the nucleotide sequences, the protein sequences, and the 3D structural data produced by X-ray crystallography and macromolecular NMR. The biological information of nucleic acids is available as sequences while the data of proteins are available as sequences and structures. Sequences are represented in a single dimension whereas the structure contains the three-dimensional data of sequences. A … Read more

Genomics

Genomics

Genome refers to the complete set of genes or genetic material present in a cell or organism while genomics is the study of genomes. Genomic studies are characterized by simultaneous analysis of a large number of genes using automated data gathering tools. Genomics is a discipline in genetics that applies recombinant DNA, DNA sequencing methods, and bioinformatics to sequence, assemble and analyze the function and structure of genomes. The advent of genomics and the ensuing explosion of sequence information are … Read more

Protein Databases- Types and Importance

Protein Databases- Types and Importance

As biology has increasingly turned into a data-rich science, the need for storing and communicating large datasets has grown tremendously. The obvious examples are the nucleotide sequences, the protein sequences, and the 3D structural data produced by X-ray crystallography and macromolecular NMR. The biological information of proteins is available as sequences and structures. Sequences are represented in a single dimension whereas the structure contains the three-dimensional data of sequences. A biological database is a collection of data that is organized … Read more

In Silico drug designing and role of bioinformatics

drug designing

“In Silico” is an expression used to mean “performed on computer or via computer simulation.”  In Silico drug designing is thus the identification of the drug target molecule by employing bioinformatics tools. The inventive process of finding new medications based on the knowledge of a biological target is called as drug designing. It can be accomplished in two ways: Ligand based drug design Relies on knowledge of other molecules that bind to the biological target of interest. Structure-based drug design Relies on knowledge of … Read more

How to construct a Phylogenetic tree ?

How to construct a Phylogenetic tree

A phylogenetic tree is a visual representation of the relationship between different organisms, showing the path through evolutionary time from a common ancestor to different descendants. Similarities and divergence among related biological sequences revealed by sequence alignment often have to be rationalized and visualized in the context of phylogenetic trees. Thus, molecular phylogenetics is a fundamental aspect of bioinformatics. Molecular phylogenetics is the branch of phylogeny that analyzes genetic, hereditary molecular differences, predominately in DNA sequences, to gain information on an organism’s evolutionary … Read more

FASTA and BLAST

BLAST

The number of DNA and protein sequences in public databases is very large. Searching a database involves aligning the query sequence to each sequence in the database, to find significant local alignment. BLAST and FASTA are two similarity searching programs that identify homologous DNA sequences and proteins based on the excess sequence similarity.  They provide facilities for comparing DNA and proteins sequences with the existing DNA and protein databases. They are two major heuristic algorithms for performing database searches. Working … Read more

Gene Prediction- Importance and Methods

Gene Prediction

Gene prediction by computational methods for finding the location of protein coding regions is one of the essential issues in bioinformatics. Gene prediction basically means locating genes along a genome. Also called gene finding, it refers to the process of identifying the regions of genomic DNA that encode genes. This includes protein coding genes, RNA genes and other functional elements such as the regulatory genes. Importance of Gene Prediction Helps to annotate large, contiguous sequences Aids in the identification of fundamental and … Read more