Secondary Databases

Secondary Databases

Secondary Databases A biological database is a large, organized body of persistent data, usually associated with computerized software designed to update, query, and retrieve components of the data stored within the system. The chief objective of the development of a database is to organize data in a set of structured records to enable easy retrieval of information. … Read more Secondary Databases

Homology Modeling- Working, Steps, and Uses

Homology Modeling- Working, Steps, and Uses

Homology Modeling- Working, Steps, and Uses Homology modeling is also known as comparative modeling predicts protein structures based on sequence homology with known structures. It is based on the principle that “if two proteins share a high enough sequence similarity, they are likely to have very similar three-dimensional structures.” It hence relies on the identification … Read more Homology Modeling- Working, Steps, and Uses

Nucleotide sequences database

Nucleotide sequences database

Nucleotide sequences database As biology has increasingly turned into a data-rich science, the need for storing and communicating large datasets has grown tremendously. The obvious examples are the nucleotide sequences, the protein sequences, and the 3D structural data produced by X-ray crystallography and macromolecular NMR. The biological information of nucleic acids is available as sequences … Read more Nucleotide sequences database

Genomics

Genomics

Genomics Genome refers to the complete set of genes or genetic material present in a cell or organism while genomics is the study of genomes. Genomic studies are characterized by simultaneous analysis of a large number of genes using automated data gathering tools. Genomics is a discipline in genetics that applies recombinant DNA, DNA sequencing … Read more Genomics

Difference between genomics and proteomics (genomics vs proteomics)

Difference Between Genomics and Proteomics

Difference Between Genomics and Proteomics Genomics and proteomics are closely-related fields. The main difference between genomics and proteomics is that genomics is the study of the entire set of genes in the genome of a cell whereas proteomics is the study of the entire set of proteins produced by the cell. S.N. Character Genomics Proteomics 1.       Definition Genomics is … Read more Difference between genomics and proteomics (genomics vs proteomics)

Protein Databases- Types and Importance

Protein Databases- Types and Importance

Protein Databases- Types and Importance As biology has increasingly turned into a data-rich science, the need for storing and communicating large datasets has grown tremendously. The obvious examples are the nucleotide sequences, the protein sequences, and the 3D structural data produced by X-ray crystallography and macromolecular NMR. The biological information of proteins is available as sequences … Read more Protein Databases- Types and Importance

In Silico drug designing and role of bioinformatics

drug designing

In Silico drug designing and role of bioinformatics “In Silico” is an expression used to mean “performed on computer or via computer simulation.”  In Silico drug designing is thus the identification of the drug target molecule by employing bioinformatics tools. The inventive process of finding new medications based on the knowledge of a biological target is called as drug designing. … Read more In Silico drug designing and role of bioinformatics

How to construct a Phylogenetic tree ?

How to construct a Phylogenetic tree

How to construct a Phylogenetic tree ? A phylogenetic tree is a visual representation of the relationship between different organisms, showing the path through evolutionary time from a common ancestor to different descendants. Similarities and divergence among related biological sequences revealed by sequence alignment often have to be rationalized and visualized in the context of phylogenetic … Read more How to construct a Phylogenetic tree ?

FASTA and BLAST

BLAST

FASTA and BLAST The number of DNA and protein sequences in public databases is very large. Searching a database involves aligning the query sequence to each sequence in the database, to find significant local alignment. BLAST and FASTA are two similarity searching programs that identify homologous DNA sequences and proteins based on the excess sequence … Read more FASTA and BLAST

Gene Prediction- Importance and Methods

Gene Prediction

Gene Prediction- Importance and Methods Gene prediction by computational methods for finding the location of protein coding regions is one of the essential issues in bioinformatics. Gene prediction basically means locating genes along a genome. Also called gene finding, it refers to the process of identifying the regions of genomic DNA that encode genes. This includes protein … Read more Gene Prediction- Importance and Methods

The Earth BioGenome Project (EBP)

The Earth BioGenome Project (EBP)

The Earth BioGenome Project (EBP) The Earth BioGenome Project (EBP) is a global initiative to sequence the genetic code of the entire planet’s eukaryotes; some 1.5 million known species including all known plants, animals, protozoa and fungi. It aims to sequence and catalog the genomes of all such eukaryotic species over a period of ten … Read more The Earth BioGenome Project (EBP)

The Human Genome Project

The Human Genome Project

The Human Genome Project The start of the human genome project in the late 1980s provided a major boost for the development of bioinformatics. The Human Genome Project (HGP) was the international, collaborative research program whose goal was the complete mapping and understanding of all the genes of human beings. The Project was coordinated by … Read more The Human Genome Project

Biological Databases- Types and Importance

Biological Databases- Types and Importance

Biological Databases- Types and Importance One of the hallmarks of modern genomic research is the generation of enormous amounts of raw sequence data. As the volume of genomic data grows, sophisticated computational methodologies are required to manage the data deluge. Thus, the very first challenge in the genomics era is to store and handle the … Read more Biological Databases- Types and Importance