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Immunology

Immunology is an emerging branch of medical science that deals with studies related to different aspects of the immune system like the cells, structure, function, response against antigens, and disorders.

  • The immune system consists of a collection of cells, chemicals, processes, and mechanisms that function to protect the body from foreign antigens, such as microbes (organisms such as bacteria, fungi, and parasites), viruses, cancer cells, and toxins.
  • Beyond, the structural and chemical barriers which protect us from infection, the immune system consists of two lines of defense; innate immunity and adaptive immunity.
  • The innate immunity represents the first line of defense against the antigen, and it is an antigen-independent defense mechanism used by the host immediately or within hours of encountering an antigen.
  • On the other hand, adaptive immunity is antigen-dependent and antigen-specific and, therefore, includes a lag time between exposure to the antigen and maximal response.
  • Studies conducted in immunology are related to the measurement of physiological functioning of the immune system in both healthy and disease conditions, malfunctioning of the system in the case of disorders, and physical, chemical, and physiological characteristics of the cells of the immune system.
  • Immunology is fast becoming an important branch of clinical medicine as it has a close relationship with organ transplantation, oncology, virology, bacteriology, and even dermatology.
  • Immunology is focused on certain organs of the body like the bone marrow and the lymphatic system and the white blood cells found in the blood.
  • These cells or organs producing these cells are responsible, directly or indirectly, for the defense mechanism of the body against a pathogenic agent or other antigens.
  • These cells keep on circulating throughout the body via blood or lymph so that they can detect antigens entering the body from different sources.
  • An important aspect of immunology is immunotherapy, where components of the immune system or antigens are used to treat a disease or disorder as a form of treatment.

Immunogens: Features, Types, Factors, Applications

June 15, 2026June 3, 2026 by Kritisha Guragain
Immunogens

Immunogens are substances that, when introduced into the body, are capable of inducing a specific immune response (such as production of antibodies or activation of T cells) in a susceptible … Read more

Hapten: Definition, Discovery, Examples, Features, Applications

June 15, 2026June 2, 2026 by Agrani Paudel
Hapten

Antigen, Immunogen, and Hapten Antigen Immunogen It is any antigen that produces a humoral or cell-mediated immune response Note: All immunogens are antigens, but not all antigens are immunogenic Complete vs. … Read more

Epitopes: Size, Location, Types, Mapping, and Importance

June 15, 2026June 1, 2026 by Agrani Paudel
Epitopes

An epitope or antigenic determinant is a specific region or a molecular sequence present on the surface of an antigen that is recognized by a receptor of a B-cell or … Read more

CAR-T Cell Therapy: Structure, Mechanism, Process, Types, Applications

June 14, 2026May 30, 2026 by Monima Karmacharya
CAR-T Cell Therapy

Chimeric Antigen Receptor (CAR) T Cell Therapy is a cell-based immunotherapy that genetically modifies a person’s T cells to recognize and destroy cancer cells. In this therapy, autologous T cells … Read more

Immunoglobulin G (IgG): Structure, Subclasses and Functions

May 10, 2026May 9, 2026 by Sagar Aryal, PhD
Immunoglobulin G (IgG)

Structure of Immunoglobulin G (IgG) IgG Subclasses IgG1 It comprises 60 to 65% of the total main subclass IgG, and predominantly responsible for the thymus-mediated immune response against proteins and polypeptide … Read more

mRNA Vaccines: Structure, Components, Principle, Production, Applications

May 9, 2026May 7, 2026 by Saman Bhattarai
mRNA Vaccines

mRNA vaccines are suspensions of active (live) or inactivated microorganisms, toxins, or other disease-causing entities. Generally, weakened or inactivated components of pathogens or their antigenic proteins activate the immune system … Read more

Indirect ELISA: Principle, Steps, Protocol, Applications

April 23, 2026April 19, 2026 by Shubhechchha Maharjan
Indirect ELISA

Indirect ELISA (Enzyme-Linked Immunosorbent Assay) is a type of ELISA that is widely used for detecting and quantifying antibodies in samples such as serum and other biological fluids. It is … Read more

Phagocytosis: Phagocytes, Steps, Mechanisms, Examples

April 18, 2026April 17, 2026 by Kritisha Guragain
Phagocytosis

Phagocytosis is the process by which cells are used for the ingestion and degradation of particles larger than 0.5µm in diameter, such as microorganisms, foreign bodies, and apoptotic cells. This … Read more

iNKT Cells: Development, Maturation, Activation, Roles

April 17, 2026April 13, 2026 by Kritisha Guragain
iNKT cells

Invariant Natural Killer T (iNKT) cells are a unique subset of lymphocytes that share characteristics of both natural killer cells and αβ T cells. They are characterized by a semi-invariant … Read more

Severe Combined Immunodeficiency (SCID): An Overview

March 22, 2026 by Khushi Sharma
Severe Combined Immunodeficiency (SCID)

Causes of Severe Combined Immunodeficiency (SCID) Types and mechanisms of Severe Combined Immunodeficiency (SCID) X-linked SCID (SCID-X1) Adenosine Deaminase (ADA) Deficiency Recombinase-Activating Gene (RAG) Deficiency Clinical Presentation and Diagnosis of … Read more

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