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Sagar Aryal, PhD

Dr. Sagar Aryal is a microbiologist, researcher, and science communicator from Nepal. He is also co-founder and Research Head of the Department of Natural Products at the Kathmandu Research Institute for Biological Sciences (KRIBS), where he leads research on natural product discovery and microbial biodiversity. Dr. Aryal earned his Ph.D. in Microbiology from Tribhuvan University, Kathmandu, Nepal, in 2025, supported by a DAAD Research Grant and a University Grants Commission (UGC) Nepal Ph.D. Fellowship. His research interests include Actinomycetes, Myxobacteria, microbial taxonomy, and natural products, particularly the discovery of bioactive compounds with potential pharmaceutical applications. He isolated and identified Nocardia nepalensis, a novel bacterial species from Nepal, contributing to understanding microbial diversity in the region. Dr. Aryal has published more than 16 research articles in international journals and contributed three book chapters to established academic publications. He has presented scientific research findings and developed international research collaborations through visits to more than 18 countries across Asia, Europe, North America, and Oceania. From 2023 to 2025, he served as the American Society for Microbiology (ASM) Young Ambassador to Nepal. Since December 2025, he has served as an Editorial Board Member of Scientific Reports, a Nature Portfolio journal. In recognition of his scientific contributions, Dr. Aryal received the NAST Science and Technology Youth Award 2025 from the Nepal Academy of Science and Technology. He previously received the Frs. Locke and Stiller Research Award (LSRA) for the 2017-2018 cycle from St. Xavier's College, Kathmandu, and a Nepal Academy of Science and Technology (NAST) Research Grant for 2017-2018. Alongside his scientific career, Dr. Aryal has more than 15 years of experience in blogging, content writing, and search engine optimization (SEO).

Amino Acids- Properties, Structure, Classification, Functions

January 9, 2023July 6, 2022 by Sagar Aryal, PhD
Amino Acids

Amino acids constitute a group of neutral products clearly distinguished from other natural compounds chemically, mainly because of their ampholytic properties, and biochemically, mainly because of their role as protein … Read more

Gene Cloning- Requirements, Principle, Steps, Applications

September 5, 2022July 6, 2022 by Sagar Aryal, PhD
Gene Cloning- Requirements, Principle, Steps, Applications

The production of exact copies of a particular gene or DNA sequence using genetic engineering techniques is called gene cloning. The term “gene cloning,” “DNA cloning,” “molecular cloning,” and “recombinant DNA technology” … Read more

Innate Immune System- An Introduction

September 15, 2022July 5, 2022 by Sagar Aryal, PhD
Innate Immune System- An Introduction

The innate immune system provides the first line of host defense against microbes, before adaptive immune responses have had sufficient time to develop. The mechanisms of innate immunity exist before … Read more

Immunoelectrophoresis: Principle, Procedure & Applications

December 30, 2024July 5, 2022 by Sagar Aryal, PhD
Immunoelectrophoresis- Principle, Procedure, Results and Applications

Principle of Immunoelectrophoresis When an electric current is applied to a slide layered with gel, the antigen mixture placed in wells is separated into individual antigen components according to their … Read more

Isolation of Bacillus thuringiensis (Bt) from Soil sample

September 5, 2022July 5, 2022 by Sagar Aryal, PhD
Isolation of Bacillus thuringiensis (Bt) from Soil sample

Bacillus thuringiensis (Bt) is an ubiquitous, Gram-positive and sporulating bacterium that synthesizes insecticidal proteins with specificity against a wide range of insects during sporulation (Cry and Cyt) and vegetative growth (Vip … Read more

Radial Immunodiffusion- Principle, Procedure, Results, Uses

September 5, 2022July 4, 2022 by Sagar Aryal, PhD
Result Interpretation of Radial Immunodiffusion

Immuno-diffusion is a technique for the detection or measurement of antibodies and antigens by their precipitation which involves diffusion through a substance such as agar or gel agarose. Simply, it … Read more

Ring Precipitation Test- Principle, Procedure, Results, Examples

October 20, 2026July 4, 2022 by Sagar Aryal, PhD
Results Interpretation of Ring Precipitation Test

Interactions of antibodies and antigens, in the form of various tests, have been developed to determine the presence or absence of antibodies or antigens in a sample.  A type of … Read more

Immunoglobulin E (IgE)- Definition, Structure and Functions

September 5, 2022July 2, 2022 by Sagar Aryal, PhD
Immunoglobulin E (IgE)- Structure and Functions

Immunoglobulin E (IgE) Definition Immunoglobulin E (IgE) is one of the 5 classes of immunoglobulins, which is defined by the presence of epsilon (ε) heavy chain. It is present in … Read more

Anatomical Barriers of Immune System- Skin and Mucus

September 5, 2022July 1, 2022 by Sagar Aryal, PhD
Anatomical Barriers of Immune System- Skin and Mucus

Before a microbe or parasite can invade the host and cause infection, it must first attach to and penetrate the surface epithelial layers of the body. Organisms gain entrance into … Read more

Enterotoxigenic E. coli (ETEC): Characteristics, Virulence, Diarrhea & Diagnosis

September 26, 2026July 1, 2022 by Sagar Aryal, PhD
Enterotoxigenic E. coli (ETEC)

Image Source: CDC and Johns Hopkins Bloomberg School of Public Health Disease Caused Mode of Transmission The infections are primarily acquired through consumption of fecally contaminated food or water. Person-to-person … Read more

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