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Immunology

Immunology is an emerging branch of medical science that deals with studies related to different aspects of the immune system like the cells, structure, function, response against antigens, and disorders.

  • The immune system consists of a collection of cells, chemicals, processes, and mechanisms that function to protect the body from foreign antigens, such as microbes (organisms such as bacteria, fungi, and parasites), viruses, cancer cells, and toxins.
  • Beyond, the structural and chemical barriers which protect us from infection, the immune system consists of two lines of defense; innate immunity and adaptive immunity.
  • The innate immunity represents the first line of defense against the antigen, and it is an antigen-independent defense mechanism used by the host immediately or within hours of encountering an antigen.
  • On the other hand, adaptive immunity is antigen-dependent and antigen-specific and, therefore, includes a lag time between exposure to the antigen and maximal response.
  • Studies conducted in immunology are related to the measurement of physiological functioning of the immune system in both healthy and disease conditions, malfunctioning of the system in the case of disorders, and physical, chemical, and physiological characteristics of the cells of the immune system.
  • Immunology is fast becoming an important branch of clinical medicine as it has a close relationship with organ transplantation, oncology, virology, bacteriology, and even dermatology.
  • Immunology is focused on certain organs of the body like the bone marrow and the lymphatic system and the white blood cells found in the blood.
  • These cells or organs producing these cells are responsible, directly or indirectly, for the defense mechanism of the body against a pathogenic agent or other antigens.
  • These cells keep on circulating throughout the body via blood or lymph so that they can detect antigens entering the body from different sources.
  • An important aspect of immunology is immunotherapy, where components of the immune system or antigens are used to treat a disease or disorder as a form of treatment.

Antibody: Definition, Structure, Types, Forms, Functions

July 16, 2024August 3, 2023 by Faith Mokobi
Antibodies- Definition, Structure, Types, Forms, Functions

Antibodies are protein molecules naturally produced or synthesized by the B-lymphocytes. They are also known as Immunoglobulins. The use of the term antibody defines an Immunoglobulin molecule that has specificity … Read more

What is Inflammation? An Introduction

August 3, 2023June 28, 2023 by Sagar Aryal, PhD
Inflammation

(a) Margination: With the decrease in blood flow rate, leucocytes flow nearer to the vessel wall. (b) Rolling on endothelium:  They roll along the surface of the endothelium and line-up … Read more

Complement System and Classical pathway

August 3, 2023June 16, 2023 by Deepa Pudasaini
The Classical pathway of the complement system

The complement system constitutes a cascade of interactions between a large number of heat-labile plasma proteins called complements. These proteins are inactively circulating in the plasma and are functional when … Read more

Serum vs. Plasma (17 Major Differences)

June 4, 2023June 1, 2023 by Sagar Aryal, PhD
Differences between Serum and Plasma

S.N. Characteristics Serum Plasma 1. Definition The clear yellow fluid separated when blood is allowed to clot freely. Yellowish and slight alkaline fluid, in which blood cells float. 2. Clotting … Read more

Antigen: Properties, Structure, Types, Examples

August 3, 2023March 30, 2023 by Anupama Sapkota
Antigen- Definition, Properties, Structure, Types, Examples

Antigens are molecules or molecular structures that are foreign to the body and generally induce an immune reaction in the form of the production of antibodies against them. Properties of … Read more

Hemagglutination Assay- Principle, Types, Method, Uses

January 13, 2023December 13, 2022 by Bikash Dwivedi
Hemagglutination Assay

The antigen and antibody reaction in which the antigen-antibody complex formed is visible in the form of clumps is called agglutination. It occurs on the surface of the cells or … Read more

Innate vs. Acquired Immunity (Definition, Types, Examples)

January 13, 2023November 22, 2022 by Deepa Pudasaini
Innate Immunity vs. Acquired Immunity

What is the Immune system? The immune system is the complex network of organs, cells, and proteins that protects the body against infections. This defense system proceeds via the recognition … Read more

Lectin Pathway of the complement system

September 6, 2022September 5, 2022 by Deepa Pudasaini
Lectin Pathway of the complement system

The lectin pathway (LP) proceeds like the classical pathway by activating the C3 convertase. The binding of mannose-binding proteins initiates the cascade of reactions in this pathway in blood plasma … Read more

Apoptosis- Definition, Pathways, Assay, Examples (vs Necrosis)

September 17, 2022August 22, 2022 by Anupama Sapkota
Apoptosis

Apoptosis is a normal genetically programmed cell death where an aging cell at the end of its life cycle shrinks and its remaining fragments are phagocytosed without any inflammatory reaction. … Read more

Alternative pathway of the complement system

January 9, 2023August 17, 2022 by Deepa Pudasaini
Alternative pathway of the complement system

The alternative pathway (AP) is dominant to the classical and lectin pathway during normal physiological conditions. This pathway is constantly activated at a low level in which C3 gets hydrolyzed … Read more

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