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Immunology

Immunology is an emerging branch of medical science that deals with studies related to different aspects of the immune system like the cells, structure, function, response against antigens, and disorders.

  • The immune system consists of a collection of cells, chemicals, processes, and mechanisms that function to protect the body from foreign antigens, such as microbes (organisms such as bacteria, fungi, and parasites), viruses, cancer cells, and toxins.
  • Beyond, the structural and chemical barriers which protect us from infection, the immune system consists of two lines of defense; innate immunity and adaptive immunity.
  • The innate immunity represents the first line of defense against the antigen, and it is an antigen-independent defense mechanism used by the host immediately or within hours of encountering an antigen.
  • On the other hand, adaptive immunity is antigen-dependent and antigen-specific and, therefore, includes a lag time between exposure to the antigen and maximal response.
  • Studies conducted in immunology are related to the measurement of physiological functioning of the immune system in both healthy and disease conditions, malfunctioning of the system in the case of disorders, and physical, chemical, and physiological characteristics of the cells of the immune system.
  • Immunology is fast becoming an important branch of clinical medicine as it has a close relationship with organ transplantation, oncology, virology, bacteriology, and even dermatology.
  • Immunology is focused on certain organs of the body like the bone marrow and the lymphatic system and the white blood cells found in the blood.
  • These cells or organs producing these cells are responsible, directly or indirectly, for the defense mechanism of the body against a pathogenic agent or other antigens.
  • These cells keep on circulating throughout the body via blood or lymph so that they can detect antigens entering the body from different sources.
  • An important aspect of immunology is immunotherapy, where components of the immune system or antigens are used to treat a disease or disorder as a form of treatment.

Active Immunization- Advantages and Drawbacks

September 5, 2022June 25, 2022 by Sagar Aryal, PhD
Active Immunization- Advantages and Drawbacks

What is Active Immunization? Immunizationย is the process whereby a person naturally acquires or is induced to acquire immunity or resistance to an infectious disease. An individual can acquire such immunity … Read more

Immunoglobulin G (IgG)- Structure, Subclasses and Functions

September 5, 2022June 24, 2022 by Sagar Aryal, PhD
Immunoglobulin G (IgG)- Structure, Subclasses and Functions

Antibodies, or โ€˜immunoglobulinsโ€™, are glycoproteins that bind antigens with high specificity and affinity. In humans there are five chemically and physically distinct classes of antibodies (IgG, IgA, IgM, IgD, IgE). … Read more

Spleen: Definition, Structure and Functions

March 6, 2024June 23, 2022 by Sagar Aryal, PhD
Spleen

The spleen is a large, encapsulated, bean-shaped organ that is situated on the left side of the body below the diaphragm. The spleen contains T and B lymphocytes as well … Read more

Bone Marrow- Types, Structure and Functions

September 5, 2022June 15, 2022 by Sagar Aryal, PhD
Bone Marrow- Types, Structure and Functions

Bone Marrowย is the soft, highly vascular and flexibleย connective tissue within bone cavities which serve as the primary site of new blood cell production orย hematopoiesis. In adult humans, bone marrow is … Read more

Passive immunization with advantages and drawbacks

September 5, 2022June 14, 2022 by Sagar Aryal, PhD
Passive immunization with advantages and drawbacks

Immunizationย is the process whereby a person naturally acquires or is induced to acquire immunity or resistance to an infectious disease. An individual can acquire such immunity either passively or actively … Read more

Complement- Properties and Nomenclature

September 5, 2022June 13, 2022 by Sagar Aryal, PhD
Complement- Properties and Nomenclature

Complement refers to a set of serum proteins that cooperates with both the innate and the adaptive immune systems to eliminate blood and tissue pathogens. Various complement components bind and … Read more

Lymph Nodes- Structure and Functions

September 5, 2022June 13, 2022 by Sagar Aryal, PhD
Lymph Nodes- Structure and Functions

Lymph nodes are small solid structures placed at varying points along the lymphatic system such as the groin, armpit and mesentery. They contain both T and B lymphocytes as well … Read more

Major Histocompatibility Complex II- Structure, Mechanism and Functions

September 5, 2022June 12, 2022 by Sagar Aryal, PhD
Major Histocompatibility Complex II- Structure, Mechanism and Functions

Major Histocompatibility Complex (MHC) is a part of the genome of all vertebrates that code for molecules which are important in immune recognition. In humans, the MHC is a cluster … Read more

Thymus- Structure and Functions

September 5, 2022June 11, 2022 by Sagar Aryal, PhD
Thymus- Structure and Functions

The thymus is a lymphocyte-rich, bilobed, encapsulated organ located behind the sternum, above and in front of the heart. The activity of the thymus is maximal in the fetus and … Read more

Type IV (Cell Mediated) Hypersensitivity- Mechanism and Examples

September 5, 2022June 11, 2022 by Sagar Aryal, PhD
Type IV (Cell Mediated) Hypersensitivity- Mechanism and Examples

Hypersensitivity refers to increased reactivity or exaggerated immune response of a host to an antigen to which it has been previously exposed. According to the most widely accepted classification of … Read more

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