Mycobacterium tuberculosis- An Overview

Mycobacterium tuberculosis

Habitat of Mycobacterium tuberculosis Human is only a known reservoir. Usually found in the lungs but can also live in any part of the body. They may be obligate pathogen, facultative or opportunistic pathogens, or free living. Usually infect the mono-nuclear phagocytes. Can also be infected by the consumption of unpasteurized milk. Can survive for weeks in the dust, on …

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WHO Global Tuberculosis Report 2018

WHO Global Tuberculosis Report 2018

WHO Global Tuberculosis Report 2018 WHO has published a global TB report every year since 1997. The main aim of the report is to provide a comprehensive and up-to-date assessment of the TB epidemic, and of progress in prevention, diagnosis and treatment of the disease at global, regional and country levels. This is done in the context of recommended global …

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Laboratory diagnosis, treatment and prevention of Tuberculosis

Laboratory diagnosis, treatment and prevention of Tuberculosis

Laboratory diagnosis of Tuberculosis caused by Mycobacterium tuberculosis Specimen and processing sputum, bronchial washings, brushings or biopsies or early morning gastric aspirates, Cerebospinal Fluid (CSF), urine Specimens from sputum and other nonsterile sites should be liquefied with N-acetyl-L-cysteine decontaminated with NaOH (kills many other bacteria and fungi), neutralized with buffer, and concentrated by centrifugation. Specimens from sterile sites, such as …

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Pathogenesis and Clinical manifestation of Mycobacterium tuberculosis

Pathogenesis and Clinical manifestation of Mycobacterium tuberculosis

Virulence factors of Mycobacterium tuberculosis A. Mycolic acid and Lipoarabinomannan (LAM) Waxy layer that protects the bacteria from many host factors and also to many antibiotics including beta lactamases. Muramyl dipeptide (from peptidoglycan) complexed with mycolic acids can cause granuloma formation, phospholipids induce caseous necrosis. LAM is structurally and functionally related to the O antigenic lipopolysaccharides of other bacteria. Biological …

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