Bacteremia

Klebsiella pneumoniae- Pathogenicity and Clinical Manifestations

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Klebsiella pneumoniae- Pathogenicity and Clinical Manifestations

Klebsiella pneumoniae is a gram-negative, encapsulated, non-motile bacterium that is found in the environment and has been associated with pneumonia in the alcoholic and diabetic patient population. K. pneumoniae is also a well-known cause of community-acquired pneumonia. The bacterium typically colonizes human mucosal surfaces of the oropharynx and gastrointestinal (GI) tract. K. pneumoniae is present in the respiratory tract and …

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Virulence factors, Pathogenesis and Clinical manifestations of Streptococcus pneumoniae

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Virulence factors, Pathogenesis and Clinical manifestations of Streptococcus pneumoniae

Virulence factors of Streptococcus pneumoniae Polysaccharide capsule The capsule is antiphagocytic, inhibiting complement deposition and phagocytosis. 2. Cell wall associated polymers and proteins Teichoic acid – binds to epithelial cells and activates alternative complement pathway Protein adhesion – binds to epithelial cells Peptidogylcan – activates alternative complement pathway Phosphorylcholine – mediates invasion of host cell F protein – mediates attachment …

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