Differences between Cytokines and Chemokines
Here are some differences:
|1.||Definition||Small proteins produced dominantly by immune cells which are important in cell signaling.||Specific cytokines that are specially adapted for chemotaxis of cells.|
|2.||Description||A broad family of chemical messengers serving to bring about immune response.||They are chemotactic cytokines.|
|3.||Size||~5–20 kDa||~ 8-10 kDa|
|4.||Classification||Cytokines include chemokines, interferon, interleukins, lymphokines, and tumour necrosis factor.||Chemokines have been classified into four main subfamilies: CXC, CC, CX3C and XC.|
|5.||Involvement in immunity||Involved in both humoral and cell mediated immunity.||Involved only in directing cells of the immune system to a target site.|
|6.||Functions||Help in signaling molecules that mediate and regulate immunity, inflammation and hematopoiesis.
They are also critical controllers of cell, and hence tissue, growth, migration, development and differentiation.
|Direct the migration of white blood cells to infected or damaged tissues i.e. guide cell movement towards a target location.
They are implicated in both immunological reactions and in homeostasis of the immune system.
|7.||Importance||Serves a regulatory role (acts like messengers) in immune system. The healing process following resolution of an infection is mediated by cytokines.||Helps to ensure that the infection do not spread to other parts of the body from the origin or site of detection.|
|8.||Examples||IL-1,6,12, IFN-a, TNFα, IFN-γ etc.||monocyte chemoattractant protein-1 (MCP-1 or CCL2), CCL1, CCL15, CCL21, CXCR1-7, XCL1 etc.|