Differences between Cytokines and Chemokines

Differences between Cytokines and Chemokines

Differences between Cytokines and Chemokines

Differences between Cytokines and Chemokines

Here are some differences:

S.N.

Characteristics Cytokines

Chemokines

1. Definition Small proteins produced dominantly by immune cells which are important in cell signaling. Specific cytokines that are specially adapted for chemotaxis of cells.
2. Description A broad family of chemical messengers serving to bring about immune response. They are chemotactic cytokines.
3. Size ~5–20 kDa ~ 8-10 kDa
4. Classification Cytokines include chemokines, interferon, interleukins, lymphokines, and tumour necrosis factor. Chemokines have been classified into four main subfamilies: CXC, CC, CX3C and XC.
5. Involvement in immunity Involved in both humoral and cell mediated immunity. Involved only in directing cells of the immune system to a target site.
6. Functions Help in signaling molecules that mediate and regulate immunity, inflammation and hematopoiesis.

They are also critical controllers of cell, and hence tissue, growth, migration, development and differentiation.

Direct the migration of white blood cells to infected or damaged tissues i.e. guide cell movement towards a target location.

They are implicated in both immunological reactions and in homeostasis of the immune system.

7. Importance Serves a regulatory role (acts like messengers) in immune system. The healing process following resolution of  an infection is mediated by cytokines. Helps to ensure that the infection do not spread to other parts of the body from the origin or site of detection.
8. Examples IL-1,6,12, IFN-a, TNFα, IFN-γ etc. monocyte chemoattractant protein-1 (MCP-1 or CCL2), CCL1, CCL15, CCL21, CXCR1-7, XCL1 etc.

Differences between Cytokines and Chemokines

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