Peroxisomes- Structure and Functions
- Peroxisomes are small, membrane-enclosed cellular organelles containing oxidative enzymes which are involved in a variety of metabolic reactions, including several aspects of energy metabolism.
- They are considered as an important type of microbody found in both plants and animal cells.
- They were identified as organelles by Belgian cytologist Christian de Duve in 1967 after already been described.
- First peroxisomes to be discovered were isolated from leaf homogenate of spinach.
- Peroxisomes are most abundantly found in detoxifying organs such as the liver and kidney cells. However, they can be induced to proliferate in response to metabolic needs.
Structure of Peroxisomes
Image Source: Irfan J Lodhi (DOI: 10.1016/j.cmet.2014.01.002)
- Peroxisomes are membrane-bound spherical bodies of 0.2 to 1.5 μm in diameter found in all eukaryotic organisms including both plants and animal cells.
- They are found floating freely in the cytoplasm in close association of ER, mitochondria or chloroplast within the cell.
- Peroxisomes are among the simplest of eukaryotic organelles.
- They exist either in the form of a network of interconnected tubules called peroxisome reticulum or as individual microperoxisomes.
- They are variable in size and shape according to the cell and usually circular in cross-section.
- They range from 0.2 -1.5 μm in diameter.
- It consists of a single limiting membrane of lipid and protein molecules enclosing the granular matrix.
- The matrix consists of fibrils or with a crystalloid structure containing enzymes.
- Approximately 60 known enzymes are present in the matrix of peroxisomes.
- They are responsible to carry out oxidation reactions leading to the production of hydrogen peroxide.
- The main groups of enzymes include:
- Urate oxidase
- D-amino acid oxidase
Functions of Peroxisomes
- Hydrogen Peroxide Metabolism:
- Enzymes present in the peroxisomes both lead to the production and elimination of H202 which is a reactive oxygen species.
- Fatty acid oxidation:
- Oxidation of fatty acids, in animal cells, occur in both peroxisomes and mitochondria, but in yeasts and plants, only limited to peroxisomes.
- Oxidation is accompanied by the production of H202 which is decomposed by catalase enzyme. This provides a major source of metabolic energy.
- Lipid biosynthesis
- Synthesis of cholesterol and dolichol occurs in both ER and peroxisomes. Bile acid synthesis takes place from cholesterol in the liver.
- Peroxisomes contain enzymes to synthesize plasmalogens, a family of phospholipids which are important membrane component of tissues of heart and brain.
- Germination of seeds
- Peroxisomes in seeds responsible for the conversion of stored fatty acids to carbohydrates, critical to providing energy and raw materials for the growth of germinating plant.
- Peroxisomes in leaves particularly in the green ones carry out photorespiration process along with chloroplasts.
- Degradation of purines
- Carry out the catabolism of purines, polyamines and amino acids especially by uric acid oxidase
- Luciferase enzyme found in the peroxisomes of fireflies help in bioluminescence and thus aid the flies in finding a mate or its meal.
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Peroxisomes- Structure and Functions
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