Differences between B Cells and T Cells

Differences between B Cells and T Cells

Differences between B Cells and T Cells

Differences between B Cells and T Cells

The major differences between B  lymphocytes and T lymphocytes include:

S.N. Characteristics B  lymphocytes T lymphocytes
1. Site of Maturation B lymphocytes both originate and mature in the bone marrow. T lymphocytes mature in the thymus after its origination in the bone marrow.
2. Position Mature B cells occur mostly outside the lymph node. Mature T cells occur mostly inside lymph node.
3. Distribution Germinal centres of lymph nodes, spleen, gut, respiratory tract; also subcapsular and medullary cords of lymph nodes. Parafollicular areas of cortex in lymph nodes, periarteriolar in spleen.

 

.4. Receptors The B-cell receptors (BCRs) constitute of membrane antibodies known as immunoglobulin surface receptors. Surface receptors are called T-cell receptors (TCRs) and differ from membrane antibodies.
5. Binds with Extracellular antigens such as bacteria, free viruses and other circulating free foreign material. Foreign antigen in association with self antigen only such as a virus infected cell.
6. Need of Antigen Processing Antigen processing is not necessary. Antigen processing is necessary.
7. Connection B-cells bind directly with the antigens on the surface of the invading virus or bacteria. T-cells can only bind to antigens on the outside of infected cells and not directly.
8. C3 complement receptor Receptors for C3 complement present. Receptors for C3 complement absent.
9. Cell Surface Marker CD19 is the cell surface markers of B cells. CD3 is the cell surface markers of T cells.
10. Microvilli on cell surface Present Absent
11. Types of Active Cells B cell differentiates into plasma cells and memory cells. T cell differentiates into many subsets of T cells such as Cytotoxic T cells (CD8+ T cells), Helper T cells (CD4+ T cells) and suppressors cells along with memory cells.
12. Abundance It constitutes about 20% of lymphocytes in blood. It constitutes about 80% of lymphocytes in blood.
13. Secretory Product Antibodies are the chief secretory product of B cells. Cytokines (lymphokines) are the chief secretory product of T cells.
14. Type of Immunity Involved in humoral (antibody mediated) immunity. Involved in cell mediated immunity.
15. Life Span They have comparatively a shorter life span. They have comparatively longer life span.
16. Relationship Since B cells are also Antigen Presenting cells, they present antigens to T-cells. They help to activate B cells and aid in antibody production against antigens which are T-dependent.
17. Functions Help eliminate free foreign invaders by enhancing immunity responses against them; provide immunity against most foreign antigens and bacteria. Help lyse virus-infected cells and tumor cells; provide immunity against most viruses and intracellular bacterial pathogens; help B cells in antibody production.

References

  1. https://microbiologyinfo.com/differences-between-b-cells-and-t-cells/
  2. http://education.seattlepi.com/functional-difference-between-t-cells-b-cells-4573.html
  3. http://pediaa.com/difference-between-t-cells-and-b-cells/
  4. Lydyard, P.M., Whelan,A.,& Fanger,M.W. (2005).Immunology (2 ed.).London: BIOS Scientific Publishers.

Differences between B Cells and T Cells

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