B Cells vs T Cells- Definition and 17 Key Differences

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Differences between B Cells and T Cells

Differences between B Cells and T Cells

The major differences between them are:

S.N. Characteristics B  lymphocytes (B cells) T lymphocytes (T cells)
1. Site of Maturation B lymphocytes both originate and mature in the bone marrow. T lymphocytes mature in the thymus after its origination in the bone marrow.
2. Position Mature B cells occur mostly outside the lymph node. Mature T cells occur mostly inside the lymph node.
3. Distribution Germinal centers of lymph nodes, spleen, gut, respiratory tract; also subcapsular and medullary cords of lymph nodes. Parafollicular areas of cortex in lymph nodes, periarteriolar in the spleen.
.4. Receptors The B-cell receptors (BCRs) constitute of membrane antibodies known as immunoglobulin surface receptors. Surface receptors are called T-cell receptors (TCRs) and differ from membrane antibodies.
5. Binds with Extracellular antigens such as bacteria, free viruses and other circulating free foreign material. The foreign antigen in association with self-antigen only such as a virus-infected cell.
6. The need of Antigen Processing Antigen processing is not necessary. Antigen processing is necessary.
7. Connection They bind directly with the antigens on the surface of the invading virus or bacteria. They can only bind to antigens on the outside of infected cells and not directly.
8. C3 complement receptor Receptors for C3 complement present. Receptors for the C3 complement are absent.
9. Cell Surface Marker CD19 is the cell surface markers of B cells. CD3 is the cell surface markers of T cells.
10. Microvilli on the cell surface Present Absent
11. Types of Active Cells They differentiate into plasma cells and memory cells. They differentiate into many subsets of T cells such as Cytotoxic T cells (CD8+ T cells), Helper T cells (CD4+ T cells) and suppressors cells along with memory cells.
12. Abundance It constitutes about 20% of lymphocytes in the blood. It constitutes about 80% of lymphocytes in the blood.
13. Secretory Product Antibodies are the chief secretory product of B cells. Cytokines (lymphokines) are the chief secretory product of T cells.
14. Type of Immunity Involved in humoral (antibody-mediated) immunity. Involved in cell-mediated immunity.
15. Life Span They have comparatively a shorter life span. They have a comparatively longer life span.
16. Relationship Since B cells are also Antigen Presenting cells, they present antigens to T-cells. They help to activate B cells and aid in antibody production against antigens which are T-dependent.
17. Functions Help eliminate free foreign invaders by enhancing immune responses against them; provide immunity against most foreign antigens and bacteria. Help lyse virus-infected cells and tumor cells; provide immunity against most viruses and intracellular bacterial pathogens; help B cells in antibody production.


  1. https://microbiologyinfo.com/differences-between-b-cells-and-t-cells/
  2. http://education.seattlepi.com/functional-difference-between-t-cells-b-cells-4573.html
  3. http://pediaa.com/difference-between-t-cells-and-b-cells/
  4. Lydyard, P.M., Whelan,A.,& Fanger,M.W. (2005).Immunology (2 ed.).London: BIOS Scientific Publishers.

Differences between B Cells and T Cells

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Sagar Aryal

Sagar Aryal is a microbiologist and a scientific blogger. He is doing his Ph.D. at the Central Department of Microbiology, Tribhuvan University, Kathmandu, Nepal. He was awarded the DAAD Research Grant to conduct part of his Ph.D. research work for two years (2019-2021) at Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Saarbrucken, Germany. Sagar is interested in research on actinobacteria, myxobacteria, and natural products. He is the Research Head of the Department of Natural Products, Kathmandu Research Institute for Biological Sciences (KRIBS), Lalitpur, Nepal. Sagar has more than ten years of experience in blogging, content writing, and SEO. Sagar was awarded the SfAM Communications Award 2015: Professional Communicator Category from the Society for Applied Microbiology (Now: Applied Microbiology International), Cambridge, United Kingdom (UK). Sagar is also the ASM Young Ambassador to Nepal for the American Society for Microbiology since 2023 onwards.

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