Types of Complement Fixation Test

Types of Complement Fixation Test

Complement fixation test is based on the principle that when antigen and antibodies of the IgM or the IgG classes are mixed, complement is “fixed” to the antigen-antibody complex. If this occurs on the surface of RBCs, the complement cascade will be activated and hemolysis will occur. Indirect complement fixation test It is used when … Read moreTypes of Complement Fixation Test

Complement Fixation Test- Steps, Advantages and Disadvantages

Complement Fixation Test- Steps, Advantages and Disadvantages

Complement Fixation Test It is a classic method for demonstrating the presence of antibody in patient serum. It is based on the principle that antigen-antibody complex fixes the complement. As coupling of complement has no visible effects or changes, it is necessary to use an indicator system consisting of sheep RBC and coated with anti-sheep … Read moreComplement Fixation Test- Steps, Advantages and Disadvantages