{"id":777,"date":"2022-01-05T20:33:15","date_gmt":"2022-01-05T14:48:15","guid":{"rendered":"https:\/\/immunologynotes.com\/?p=316"},"modified":"2022-01-26T04:00:30","modified_gmt":"2022-01-25T22:15:30","slug":"differences-between-mhc-class-i-and-class-ii","status":"publish","type":"post","link":"https:\/\/microbenotes.com\/differences-between-mhc-class-i-and-class-ii\/","title":{"rendered":"MHC Class I vs Class II- Definition, 15 Differences, Examples"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_65 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title \" >Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #0a0a0a;color:#0a0a0a\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #0a0a0a;color:#0a0a0a\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/microbenotes.com\/differences-between-mhc-class-i-and-class-ii\/#mhc-class-i-and-class-ii-differences-mhc-i-vs-mhc-ii\" title=\"MHC Class I and Class II differences (mhc i vs mhc ii)\">MHC Class I and Class II differences (mhc i vs mhc ii)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/microbenotes.com\/differences-between-mhc-class-i-and-class-ii\/#the-major-differences-are\" title=\"The major differences are:\">The major differences are:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/microbenotes.com\/differences-between-mhc-class-i-and-class-ii\/#references\" title=\"References\">References<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/microbenotes.com\/differences-between-mhc-class-i-and-class-ii\/#mhc-class-i-and-class-ii-differences-mhc-i-vs-mhc-ii-2\" title=\"MHC Class I and Class II differences (mhc i vs mhc ii)\">MHC Class I and Class II differences (mhc i vs mhc ii)<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"mhc-class-i-and-class-ii-differences-mhc-i-vs-mhc-ii\"><\/span><span style=\"color: #000000;\"><strong>MHC Class I and Class II differences (mhc i vs mhc ii)<\/strong><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"color: #000000;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-317\" src=\"https:\/\/microbenotes.com\/wp-content\/uploads\/2018\/06\/Differences-between-MHC-Class-I-and-Class-II.jpg\" alt=\"Differences between MHC Class I and Class II\" width=\"800\" height=\"420\" \/><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"the-major-differences-are\"><\/span><span style=\"color: #000000;\">The major differences are:<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<table style=\"width: 95.6592%;\">\n<tbody>\n<tr>\n<td style=\"width: 7.23618%;\" width=\"43\">\n<p style=\"text-align: center;\"><span style=\"color: #000000;\"><strong>S.N.<\/strong><\/span><\/p>\n<\/td>\n<td style=\"text-align: center; width: 24.8241%;\" width=\"147\"><span style=\"color: #000000;\"><strong>Characteristics<\/strong><\/span><\/td>\n<td style=\"text-align: center; width: 30.7537%;\" width=\"173\"><span style=\"color: #000000;\"><strong>MHC-I molecule<\/strong><\/span><\/td>\n<td style=\"width: 32.7639%;\" width=\"204\">\n<p style=\"text-align: center;\"><span style=\"color: #000000;\"><strong>MHC -II molecule<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 7.23618%;\" width=\"43\"><span style=\"color: #000000;\"><strong>1.<\/strong><\/span><\/td>\n<td style=\"width: 24.8241%;\" width=\"147\"><span style=\"color: #000000;\">Distribution<\/span><\/td>\n<td style=\"width: 30.7537%;\" width=\"173\"><span style=\"color: #000000;\">Present on almost all nucleated cells including platelets.<\/span><\/td>\n<td style=\"width: 32.7639%;\" width=\"204\"><span style=\"color: #000000;\">Have a restricted tissue distribution and are chiefly found on macrophages, dendritic cells, B cells, and other antigen-presenting cells only.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 7.23618%;\" width=\"43\"><span style=\"color: #000000;\"><strong>2.<\/strong><\/span><\/td>\n<td style=\"width: 24.8241%;\" width=\"147\"><span style=\"color: #000000;\">Encoding genes<\/span><\/td>\n<td style=\"width: 30.7537%;\" width=\"173\"><span style=\"color: #000000;\">MHC class I proteins are encoded by the HLA-A, HLA-B, and HLA-C genes.<\/span><\/td>\n<td style=\"width: 32.7639%;\" width=\"204\"><span style=\"color: #000000;\">MHC Class II proteins are encoded by the genes of the HLA-D region.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 7.23618%;\" width=\"43\"><span style=\"color: #000000;\"><strong>3.<\/strong><\/span><\/td>\n<td style=\"width: 24.8241%;\" width=\"147\"><span style=\"color: #000000;\">Nature of antigen presented<\/span><\/td>\n<td style=\"width: 30.7537%;\" width=\"173\"><span style=\"color: #000000;\">Antigens\u00a0presented by MHC class I molecules are of endogenous origin.<\/span><\/td>\n<td style=\"width: 32.7639%;\" width=\"204\"><span style=\"color: #000000;\">Antigens\u00a0presented by MHC class II molecules are derived from extracellular proteins.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 7.23618%;\" width=\"43\"><span style=\"color: #000000;\"><strong>4.<\/strong><\/span><\/td>\n<td style=\"width: 24.8241%;\" width=\"147\"><span style=\"color: #000000;\">Antigen<\/span><\/td>\n<td style=\"width: 30.7537%;\" width=\"173\"><span style=\"color: #000000;\">Cytosolic proteins; they sample peptides generated within the cell or those that may enter cytosol from phagosomes.<\/span><\/td>\n<td style=\"width: 32.7639%;\" width=\"204\"><span style=\"color: #000000;\">Class II molecules sample peptides outside the cell such as lysosomal proteins mostly internalized from extracellular environment.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 7.23618%;\" width=\"43\"><span style=\"color: #000000;\"><strong>5.<\/strong><\/span><\/td>\n<td style=\"width: 24.8241%;\" width=\"147\"><span style=\"color: #000000;\">Enzymes involved in peptide generation\u00a0<\/span><\/td>\n<td style=\"width: 30.7537%;\" width=\"173\"><span style=\"color: #000000;\">Cytosolic proteasome\u00a0<\/span><\/td>\n<td style=\"width: 32.7639%;\" width=\"204\"><span style=\"color: #000000;\">Endosomal and lysosomal proteases<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 7.23618%;\" width=\"43\"><span style=\"color: #000000;\"><strong>6.<\/strong><\/span><\/td>\n<td style=\"width: 24.8241%;\" width=\"147\"><span style=\"color: #000000;\">Peptide loading of MHC<\/span><\/td>\n<td style=\"width: 30.7537%;\" width=\"173\"><span style=\"color: #000000;\">Endoplasmic reticulum<\/span><\/td>\n<td style=\"width: 32.7639%;\" width=\"204\"><span style=\"color: #000000;\">Specialized vesicular compartment<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 7.23618%;\" width=\"43\"><span style=\"color: #000000;\"><strong>7.<\/strong><\/span><\/td>\n<td style=\"width: 24.8241%;\" width=\"147\"><span style=\"color: #000000;\">Peptide-loading complex<\/span><\/td>\n<td style=\"width: 30.7537%;\" width=\"173\"><span style=\"color: #000000;\">Includes the ER transporter associated with antigen processing (TAP1\/2), tapasin, the oxidoreductase ERp57, and the chaperone protein calreticulin.<\/span><\/td>\n<td style=\"width: 32.7639%;\" width=\"204\"><span style=\"color: #000000;\">Chaperones in ER; invariant chain in ER, Golgi and MHC Class II compartment\/Class II vesicle<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 7.23618%;\" width=\"43\"><span style=\"color: #000000;\"><strong>8.<\/strong><\/span><\/td>\n<td style=\"width: 24.8241%;\" width=\"147\"><span style=\"color: #000000;\">Recognizing co-receptor<\/span><\/td>\n<td style=\"width: 30.7537%;\" width=\"173\"><span style=\"color: #000000;\">They are recognized by CD8 co-receptors through the MHC Class I \u03b22 subunit.<\/span><\/td>\n<td style=\"width: 32.7639%;\" width=\"204\"><span style=\"color: #000000;\">They are recognized by CD4 co-receptors through \u03b21 and \u03b22 subunits.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 7.23618%;\" width=\"43\"><span style=\"color: #000000;\"><strong>9.<\/strong><\/span><\/td>\n<td style=\"width: 24.8241%;\" width=\"147\"><span style=\"color: #000000;\">Receptor T cell<\/span><\/td>\n<td style=\"width: 30.7537%;\" width=\"173\"><span style=\"color: #000000;\">Present antigens to CD8+\u00a0T cells.<\/span><\/td>\n<td style=\"width: 32.7639%;\" width=\"204\"><span style=\"color: #000000;\">Present antigens to CD4+\u00a0T cells.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 7.23618%;\" width=\"43\"><span style=\"color: #000000;\"><strong>10.<\/strong><\/span><\/td>\n<td style=\"width: 24.8241%;\" width=\"147\"><span style=\"color: #000000;\">Structure<\/span><\/td>\n<td style=\"width: 30.7537%;\" width=\"173\"><span style=\"color: #000000;\">MHC class I molecules consist of one membrane-spanning \u03b1 chain produced by MHC genes, and one \u03b2 chain produced by the \u03b22-microglobulin gene.<\/span><\/td>\n<td style=\"width: 32.7639%;\" width=\"204\"><span style=\"color: #000000;\">MHC class II molecules consist of two membrane-spanning chains, \u03b1 and \u03b2 both produced by MHC genes.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 7.23618%;\" width=\"43\"><span style=\"color: #000000;\"><strong>11.<\/strong><\/span><\/td>\n<td style=\"width: 24.8241%;\" width=\"147\"><span style=\"color: #000000;\">Building amino acids<\/span><\/td>\n<td style=\"width: 30.7537%;\" width=\"173\"><span style=\"color: #000000;\">Possess 8-10 <a href=\"https:\/\/microbenotes.com\/amino-acids-properties-structure-classification-and-functions\/\" target=\"_blank\" rel=\"noopener noreferrer\">amino acids<\/a>.<\/span><\/td>\n<td style=\"width: 32.7639%;\" width=\"204\"><span style=\"color: #000000;\">Possess 13-18 <a href=\"https:\/\/microbenotes.com\/amino-acids-properties-structure-classification-and-functions\/\" target=\"_blank\" rel=\"noopener noreferrer\">amino acids.<\/a><\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 7.23618%;\" width=\"43\"><span style=\"color: #000000;\"><strong>12.<\/strong><\/span><\/td>\n<td style=\"width: 24.8241%;\" width=\"147\"><span style=\"color: #000000;\">Peptide binding domains<\/span><\/td>\n<td style=\"width: 30.7537%;\" width=\"173\"><span style=\"color: #000000;\">\u00a0\u03b11 and \u03b12 are peptide binding domains.<\/span><\/td>\n<td style=\"width: 32.7639%;\" width=\"204\"><span style=\"color: #000000;\">\u03b11 and \u03b21 are peptide binding domains.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 7.23618%;\" width=\"43\"><span style=\"color: #000000;\"><strong>13.<\/strong><\/span><\/td>\n<td style=\"width: 24.8241%;\" width=\"147\"><span style=\"color: #000000;\">Invariant chain<\/span><\/td>\n<td style=\"width: 30.7537%;\" width=\"173\"><span style=\"color: #000000;\">Has no invariant chain.<\/span><\/td>\n<td style=\"width: 32.7639%;\" width=\"204\"><span style=\"color: #000000;\">Has an invariant chain.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 7.23618%;\" width=\"43\"><span style=\"color: #000000;\"><strong>14.<\/strong><\/span><\/td>\n<td style=\"width: 24.8241%;\" width=\"147\"><span style=\"color: #000000;\">Functional effect<\/span><\/td>\n<td style=\"width: 30.7537%;\" width=\"173\"><span style=\"color: #000000;\">Presence of abundant antigens target cell for destruction.<\/span><\/td>\n<td style=\"width: 32.7639%;\" width=\"204\"><span style=\"color: #000000;\">Presences of foreign antigens induce antibody production.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 7.23618%;\" width=\"43\"><span style=\"color: #000000;\"><strong>15.<\/strong><\/span><\/td>\n<td style=\"width: 24.8241%;\" width=\"147\"><span style=\"color: #000000;\">Detection Method<\/span><\/td>\n<td style=\"width: 30.7537%;\" width=\"173\"><span style=\"color: #000000;\">Serology<\/span><\/td>\n<td style=\"width: 32.7639%;\" width=\"204\"><span style=\"color: #000000;\">Serology and mixed lymphocyte reaction<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><span class=\"ez-toc-section\" id=\"references\"><\/span><span style=\"color: #000000;\"><strong>References<\/strong><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ol>\n<li><span style=\"color: #000000;\">Brooks, G. F., Jawetz, E., Melnick, J. L., &amp; Adelberg, E. A. (2010).\u00a0Jawetz, Melnick, &amp; Adelberg&#8217;s Medical Microbiology. New York: McGraw Hill Medical.<\/span><\/li>\n<li><span style=\"color: #000000;\">Chelbi, S., Dang, A., &amp; Guarda, G. (2017). Emerging Major Histocompatibility Complex Class I -Realted Functions of NLRC5. <em>Advances in Immunology<\/em> <em>, 133<\/em>, 89-119.<\/span><\/li>\n<li><span style=\"color: #000000;\">https:\/\/microbeonline.com\/difference-mhc-class-mhc-class-ii-proteins\/<\/span><\/li>\n<li><a href=\"https:\/\/www.slideshare.net\/petermassawe1\/similarities-between-class-i-and-class-ii\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000;\">https:\/\/www.slideshare.net\/petermassawe1\/similarities-between-class-i-and-class-ii<\/span><\/a><\/li>\n<\/ol>\n<h2><span class=\"ez-toc-section\" id=\"mhc-class-i-and-class-ii-differences-mhc-i-vs-mhc-ii-2\"><\/span><span style=\"color: #000000;\"><strong>MHC Class I and Class II differences (mhc i vs mhc ii)<\/strong><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n","protected":false},"excerpt":{"rendered":"<p>MHC Class I and Class II differences (mhc i vs mhc ii) The major differences are: S.N. Characteristics MHC-I molecule MHC -II molecule 1. Distribution Present on almost all nucleated &#8230; <a title=\"MHC Class I vs Class II- Definition, 15 Differences, Examples\" class=\"read-more\" href=\"https:\/\/microbenotes.com\/differences-between-mhc-class-i-and-class-ii\/\" aria-label=\"Read more about MHC Class I vs Class II- Definition, 15 Differences, Examples\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":686,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1025,1026],"tags":[1323,1324,1325,1326,1327,1329,1331],"custom":{"td_video":"","featured_image":"https:\/\/microbenotes.com\/wp-content\/uploads\/2018\/06\/Differences-between-MHC-Class-I-and-Class-II.jpg","author":{"name":"Sagar Aryal","avatar":"https:\/\/secure.gravatar.com\/avatar\/862472ea06500d4318f1ad82addb608e?s=96&d=mm&r=g"},"categories":[{"term_id":1025,"name":"Difference Between","slug":"difference-between","term_group":0,"term_taxonomy_id":1025,"taxonomy":"category","description":"Difference Between Notes. Notes on Difference Between. Online Difference Between related notes. Difference Between Notes for undergraduate and graduate students with diagrams.","parent":0,"count":89,"filter":"raw","cat_ID":1025,"category_count":89,"category_description":"Difference Between Notes. Notes on Difference Between. Online Difference Between related notes. Difference Between Notes for undergraduate and graduate students with diagrams.","cat_name":"Difference Between","category_nicename":"difference-between","category_parent":0},{"term_id":1026,"name":"Immunology","slug":"immunology","term_group":0,"term_taxonomy_id":1026,"taxonomy":"category","description":"<strong>Immunology is an emerging branch of medical science that deals with studies related to different aspects of the immune system like the cells, structure, function, response against antigens, and disorders.<\/strong>\r\n<ul>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">The immune system consists of a collection of cells, chemicals, processes, and mechanisms that function to protect the body from foreign antigens, such as microbes (organisms such as bacteria, fungi, and parasites), viruses, cancer cells, and toxins.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Beyond, the structural and chemical barriers which protect us from infection, the immune system consists of two lines of defense; innate immunity and adaptive immunity.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">The innate immunity represents the first line of defense against the antigen, and it is an antigen-independent defense mechanism used by the host immediately or within hours of encountering an antigen.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">On the other hand, adaptive immunity is antigen-dependent and antigen-specific and, therefore, includes a lag time between exposure to the antigen and maximal response.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Studies conducted in immunology are related to the measurement of physiological functioning of the immune system in both healthy and disease conditions, malfunctioning of the system in the case of disorders, and physical, chemical, and physiological characteristics of the cells of the immune system.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Immunology is fast becoming an important branch of clinical medicine as it has a close relationship with organ transplantation, oncology, virology, bacteriology, and even dermatology.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Immunology is focused on certain organs of the body like the bone marrow and the lymphatic system and the white blood cells found in the blood.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">These cells or organs producing these cells are responsible, directly or indirectly, for the defense mechanism of the body against a pathogenic agent or other antigens.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">These cells keep on circulating throughout the body via blood or lymph so that they can detect antigens entering the body from different sources.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">An important aspect of immunology is immunotherapy, where components of the immune system or antigens are used to treat a disease or disorder as a form of treatment.<\/span><\/li>\r\n<\/ul>","parent":0,"count":115,"filter":"raw","cat_ID":1026,"category_count":115,"category_description":"<strong>Immunology is an emerging branch of medical science that deals with studies related to different aspects of the immune system like the cells, structure, function, response against antigens, and disorders.<\/strong>\r\n<ul>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">The immune system consists of a collection of cells, chemicals, processes, and mechanisms that function to protect the body from foreign antigens, such as microbes (organisms such as bacteria, fungi, and parasites), viruses, cancer cells, and toxins.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Beyond, the structural and chemical barriers which protect us from infection, the immune system consists of two lines of defense; innate immunity and adaptive immunity.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">The innate immunity represents the first line of defense against the antigen, and it is an antigen-independent defense mechanism used by the host immediately or within hours of encountering an antigen.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">On the other hand, adaptive immunity is antigen-dependent and antigen-specific and, therefore, includes a lag time between exposure to the antigen and maximal response.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Studies conducted in immunology are related to the measurement of physiological functioning of the immune system in both healthy and disease conditions, malfunctioning of the system in the case of disorders, and physical, chemical, and physiological characteristics of the cells of the immune system.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Immunology is fast becoming an important branch of clinical medicine as it has a close relationship with organ transplantation, oncology, virology, bacteriology, and even dermatology.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Immunology is focused on certain organs of the body like the bone marrow and the lymphatic system and the white blood cells found in the blood.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">These cells or organs producing these cells are responsible, directly or indirectly, for the defense mechanism of the body against a pathogenic agent or other antigens.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">These cells keep on circulating throughout the body via blood or lymph so that they can detect antigens entering the body from different sources.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">An important aspect of immunology is immunotherapy, where components of the immune system or antigens are used to treat a disease or disorder as a form of treatment.<\/span><\/li>\r\n<\/ul>","cat_name":"Immunology","category_nicename":"immunology","category_parent":0}]},"_links":{"self":[{"href":"https:\/\/microbenotes.com\/wp-json\/wp\/v2\/posts\/777"}],"collection":[{"href":"https:\/\/microbenotes.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/microbenotes.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/microbenotes.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/microbenotes.com\/wp-json\/wp\/v2\/comments?post=777"}],"version-history":[{"count":0,"href":"https:\/\/microbenotes.com\/wp-json\/wp\/v2\/posts\/777\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/microbenotes.com\/wp-json\/wp\/v2\/media\/686"}],"wp:attachment":[{"href":"https:\/\/microbenotes.com\/wp-json\/wp\/v2\/media?parent=777"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/microbenotes.com\/wp-json\/wp\/v2\/categories?post=777"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/microbenotes.com\/wp-json\/wp\/v2\/tags?post=777"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}