{"id":743,"date":"2022-03-05T18:56:38","date_gmt":"2022-03-05T13:11:38","guid":{"rendered":"http:\/\/immunologynotes.com\/?p=110"},"modified":"2022-09-05T14:21:09","modified_gmt":"2022-09-05T08:36:09","slug":"b-cells-b-lymphocytes","status":"publish","type":"post","link":"https:\/\/microbenotes.com\/b-cells-b-lymphocytes\/","title":{"rendered":"Introduction to B Cells also called B-Lymphocytes"},"content":{"rendered":"

B lymphocytes, the cells that produce antibodies, were so called because in birds they were found to mature in an organ called the Bursa of Fabricius<\/strong>. In mammals, no anatomic equivalent of the bursa exists, and the early stages of B cell maturation occur in the bone marrow. Thus, B lymphocytes now refer to bone marrow\u2013derived lymphocytes.<\/span><\/p>\n

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B cells are found in the germinal centers of the lymph nodes, in the white pulp of the spleen, and in the MALT. B cells perform two important functions:<\/span><\/p>\n

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  1. They differentiate into plasma cells and produce antibodies.<\/span><\/li>\n
  2. They can present antigen to helper T cells (Act as Antigen Presenting Cells).<\/span><\/li>\n<\/ol>\n

    The major subsets of B cells are follicular B cells, marginal zone B cells, and B-1 cells<\/strong>, each of which is found in distinct anatomic locations within lymphoid tissues. Follicular B cells express highly diverse, clonally distributed sets of antibodies that serve as cell surface antigen receptors and as the key secreted effector molecules of adaptive humoral immunity. In contrast, B-1 and marginal-zone B cells produce antibodies with very limited diversity.<\/span><\/p>\n

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