Klebsiella pneumoniae- Pathogenicity and Clinical Manifestations

Klebsiella pneumoniae- Pathogenicity and Clinical Manifestations

Klebsiella pneumoniae is a gram-negative, encapsulated, non-motile bacterium that is found in the environment and has been associated with pneumonia in the alcoholic and diabetic patient population. K. pneumoniae is also a well-known cause of community-acquired pneumonia. The bacterium typically colonizes human mucosal surfaces of the oropharynx and gastrointestinal (GI) tract. K. pneumoniae is present in the respiratory tract and feces of about 5% of normal individuals. Virulence Factors Figure: Role of a capsule in K. pneumoniae virulence, Image Source: … Read more

Klebsiella pneumoniae- Lab Diagnosis, Treatment, Prevention

Klebsiella pneumoniae- Lab Diagnosis, Treatment, Prevention

Laboratory Diagnosis of Klebsiella pneumoniae In the setting of pneumonia, infection with  K. pneumoniae is confirmed by either sputum culture analysis, blood culture analysis or midstream urine depending upon the illness. The presence of gram-negative rods in Gram-stained smears suggests Klebsiella; they maybe capsulated and non-sporing. Material is inoculated into blood agar and Mac Conkey agar medium and incubated aerobically. Blood Agar: Mucoid, non-hemolytic colonies MacConkey Agar: Mucoid, lactose-fermenting (pink colored) colonies After pure cultures have been obtained by selecting colonies … Read more

Urinary Tract Infection (UTI)

Urinary Tract Infection

A urinary tract infection (UTI) is an infection that affects part of the urinary tract. The urinary system is made up of the kidneys, ureters, the urinary bladder, and the urethra. Most UTIs are restricted to infection of the bladder (cystitis), though infection may occur in any area of the urinary tract, from the kidney to urethra. The presence of bacteria in urine is called bacteriuria. It is usually regarded as significant when the urine contains 105 organisms or more per ml (108/1) in pure … Read more