Pathogenesis and Clinical manifestations of Francisella tularensis
Pathogenesis of Francisella tularensis Francisella tularensis is carried by many species of wild rodents, rabbits, beavers. Humans become infected by handling the carcasses or skin of infected animals, by inhaling infective aerosols or ingesting contaminated water, through insect vectors and by being bitten by carnivores that have themselves eaten infected animals. Humans are infected by fewer than 50 organisms by either aerosol or cutaneous routes. F. tularensis subsp. tularensis is the most virulent for humans, with an infectious dose of … Read more