Venereal Disease Research Laboratory (VDRL) Test

Result Interpretation of VDRL Test

The Venereal Disease Research Laboratory test (VDRL) is a screening test for sexually transmitted infection – syphilis caused by the spirochete bacterium Treponema pallidum.  It is a non-treponemal test, which detects antibodies IgM and IgG antibodies to lipoidal material released from damaged host cells as well as to lipoprotein-like material, and possibly cardiolipin released from the treponemes. These antibodies are … Read moreVenereal Disease Research Laboratory (VDRL) Test

Laboratory diagnosis of Syphilis caused by Treponema pallidum

Laboratory diagnosis of Syphilis caused by Treponema pallidum

Laboratory diagnosis of Syphilis caused by Treponema pallidum Specimen Samples collected from ulcers and lesions should not be contaminated with blood, microorganisms, or tissue debris. Polymerase chain reaction (PCR) samples should be collected on a sterile Dacron or cotton swab and placed in a cryotube containing nucleic acid transport medium or universal transport medium. Tissue … Read moreLaboratory diagnosis of Syphilis caused by Treponema pallidum

Pathogenesis and Clinical manifestations of Treponema pallidum

Pathogenesis and Clinical manifestations of Treponema pallidum

Pathogenesis of Treponema pallidum The two major routes of transmission of Treponema pallidum are sexual and transplacental. Sexual exposure to a person who has an active syphilitic chancre carries a high probability of acquiring syphilis. The organisms enter a susceptible host by penetration of intact mucous membranes or the minute abrasions in the skin surface … Read morePathogenesis and Clinical manifestations of Treponema pallidum