Frameshift Mutation- Definition, Causes, Mechanism, Applications, Examples

Frameshift Mutation

Frameshift mutation definition A frameshift mutation is a type of genetic mutation resulting from the alteration of a number of nucleotides in DNA sequences that are not multiple of three. Frameshift mutation occurs as a result of a change in the reading frame of the sequence. Since the codons for gene expression occur in the form of triplets, the difference in nucleotides results in the change in the frame. As a result of the change in the reading frame, a … Read more

Silent Mutation- Definition, Causes, Mechanism, Applications, Examples

Silent Mutation

What are Silent mutations? Silent mutations are mutations where the changes in the nucleotide sequence of DNA do not produce any observable effect on the organism. The change in nucleotide doesn’t produce a change in the amino acid sequence or the structure and function of the protein. Silent mutations are also termed neutral mutations as these do not cause any alteration in the protein product formed. Silent mutations are possible due to the fact that multiple codon sequences can code … Read more

Nonsense Mutation- Definition, Causes, Mechanism, Applications, Examples

Nonsense Mutation

Nonsense mutation definition A nonsense mutation is a type of mutation where a premature stop codon is added to a sequence which hinders the further translation of the protein-coding gene. The nonsense mutation is classified as a loss-of-function change where the mutation impairs the production of a particular protein. Nonsense mutation, like most other mutations, can have a range of effects on the production and function of proteins. However, since shortened protein products are easily digested by proteasomes, a nonsense … Read more

Missense Mutation- Definition, Causes, Mechanism, Types, Examples

Missense-Mutation

Missense mutation definition A missense mutation is a type of mutation where the alteration of a nucleotide base in a gene sequence results in the translation of different amino acids in the protein. A missense mutation is a type of nonsynonymous substitution in a DNA sequence, indicating that the mutation results in some kind of effect on the resulting sequence. The effect caused by missense mutation, however, depends on the location of the mutation and the nucleotide.  In some cases, … Read more

Point mutation- Definition, Causes, Mechanism, Types, Examples, Applications

Point mutation

Point mutation definition Point mutation is a type of genetic mutation where one of the base pairs in the DNA sequence is altered either by insertion or deletion. Point mutation, as the name indicates, occurs at a particular point of the DNA sequence as a result of changes in one particular base pair. Usually, point mutations arise as a result of mistakes during DNA replication; however, in some cases, modification of DNA can be induced by X-rays or ultraviolet radiation. … Read more

Types of Mutations

Types of Mutations

The mutation is a process that produces a gene or chromosome that differs from the wild type (arbitrary standard for what “normal” is for an organism). The mutation may result due to changes either on the gene or the chromosome itself. Thus, broadly mutation maybe: Gene mutation where the allele of a gene changes. Chromosome mutation where segments of chromosomes, whole chromosomes, or entire sets of chromosomes change. Types of Mutations There are various schemes for classification of different kind … Read more