Novobiocin Susceptibility Test- Principle, Procedure, Results, Uses

Result Interpretation of Novobiocin Susceptibility Test

Objectives of Novobiocin Susceptibility Test To determine the susceptibility pattern of a bacterium to novobiocin. To distinguish or differentiate Staphylococcus saprophyticus from other coagulase-negative staphylococci. Principle of Novobiocin Susceptibility Test Novobiocin is an antibiotic interfering with the unpackaging and repackaging of DNA during DNA replication and the bacterial cell cycle. Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity.  Laboratory identification of S. …

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