Immunoglobulin Archives | Microbe Notes

Antibody- Definition, Structure, Properties, Types, Classes, Applications

April 4, 2021 by Anupama Sapkota

Antibody Definition Antibodies, also known as immunoglobulins, are proteins produced by lymphocytes as a result of interaction with antigens. Antibodies are a part of the humoral immune of the adaptive immune system where each antibody identifies a specific antigen and protects the body against it. Antibodies are glycoproteins that bind to antigens with a high degree of specificity and affinity. B …

Immunoglobulin E (IgE)- Structure and Functions

February 4, 2021July 2, 2018 by Sagar Aryal

Immunoglobulin E (IgE) is one of the 5 classes of immunoglobulins, which is defined by the presence of epsilon (ε) heavy chain. It is present in circulation at very low concentrations of less than 1 µg/mL which is approximately 300-fold lower than that of IgG. Although least abundant, it is in many respects the most potent of the various antibody …

Immunoglobulin M (IgM)- Structure and Functions

February 4, 2021June 26, 2018 by Sagar Aryal

Immunoglobulin M (IgM) is an antigen receptor on B cells and the first antibody produced in an immune response. It is present both on B cells, and as a soluble molecule in the blood. Because of its large size (900 kDa), IgM is found primarily in the intravascular space i.e. in the bloodstream and also lymph fluid. Serum IgM exists …

Immunoglobulin A (IgA)- Structure, Subclasses and Functions

February 4, 2021June 25, 2018 by Sagar Aryal

Antibodies, or ‘immunoglobulins’, are glycoproteins that bind antigens with high specificity and affinity. In humans there are five chemically and physically distinct classes of antibodies (IgG, IgA, IgM, IgD, IgE). Immunoglobulin A (IgA), is the major class of antibody present in the mucosal secretions of most mammals. It is the key first line of defence against invasion by inhaled and …