Folic acid synthesis inhibitors- Definition, Examples, Inhibition, Resistance

Folic acid synthesis inhibitors

Folic acids are the enzymes that are necessary for the bacterial protein synthesis and synthesis of amino acids. Trimethoprim and Sulfonamides are the antimicrobial classes that interfere with the synthesis of folic acid at different levels and are bacteriostatic. Trimethoprim and Sulfonamides are used as combination therapy in treating different infections like Traveller’s Diarrhoea, UTI, etc due to their synergistic mechanisms. Sulfonamides are the widely used antimicrobials that are used because of their efficacy. Trimethoprim prevents bacterial DNA synthesis that … Read more