Mycolic acid biosynthesis inhibitors- Definition, Examples, Inhibition, Resistance

Mycolic acid biosynthesis inhibitors

Mycolic acid is the cell wall that contains α-alkylated β-hydroxylated fatty acids present in Mycobacteria, Nocardia, and Corynebacteria. Mycolic acids are the main component of the cell wall of Mycobacterium spp and plays important role in the virulence and permeability of the outer membrane. To control the cell fluidity, trans-cyclopropanes are present in Mtb in mycolate series but in virulent series, oxygenated forms are present along with trans-cyclopropane. Disrupting the mycolic acid pathway with the help of effective treatment is … Read more