Coomb’s Test- Direct and Indirect Coomb’s Test

Result Interpretation of Coomb's Test

Coomb’s test is a direct agglutination reaction, more commonly known as antiglobulin test. It was discovered by Coombs, Mourant and Race in 1945 originally for the detection of incomplete anti-Rh antibodies. In the test, incomplete antibodies do not agglutinate erythrocytes. Incomplete antibody antiglobulin coats the surface of erythrocytes but does not cause any agglutination. When such erythrocytes are treated with antiglobulin or Coombs’ serum then the cells are agglutinated. Coombs’ Serum or Coomb’s reagent is a special serum from a … Read more