Classical Pathway of Complement Activation

Classical Pathway of Complement Activation

The classical pathway is a chain of events in which complement components react in specific sequences as a cascade resulting in cell lysis. It is activated by antibody bound to antigen (Antigen-Antibody complex) but never by native or free antibody. … Read more

Types of Complement Fixation Test

Types of Complement Fixation Test

Complement fixation test is based on the principle that when antigen and antibodies of the IgM or the IgG classes are mixed, complement is “fixed” to the antigen-antibody complex. If this occurs on the surface of RBCs, the complement cascade … Read more

Complement- Properties and Nomenclature

Complement- Properties and Nomenclature

Complement refers to a set of serum proteins that cooperates with both the innate and the adaptive immune systems to eliminate blood and tissue pathogens. Various complement components bind and opsonize bacteria, rendering them susceptible to receptor-mediated phagocytosis by macrophages, … Read more