Complement- Properties and Nomenclature

Complement- Properties and Nomenclature

Complement- Properties and Nomenclature Complement refers to a set of serum proteins that cooperates with both the innate and the adaptive immune systems to eliminate blood and tissue pathogens. Various complement components bind and opsonize bacteria, rendering them susceptible to receptor-mediated phagocytosis by macrophages, which express membrane receptors for complement proteins. Other complement proteins elicit … Read moreComplement- Properties and Nomenclature

Classical Pathway of Complement Activation

Classical Pathway of Complement Activation

The classical pathway is a chain of events in which complement components react in specific sequences as a cascade resulting in cell lysis. It is activated by antibody bound to antigen (Antigen-Antibody complex) but never by native or free antibody. These complexes may be soluble, or they may be formed when an antibody binds to … Read moreClassical Pathway of Complement Activation

Types of Complement Fixation Test

Types of Complement Fixation Test

Complement fixation test is based on the principle that when antigen and antibodies of the IgM or the IgG classes are mixed, complement is “fixed” to the antigen–antibody complex. If this occurs on the surface of RBCs, the complement cascade will be activated and hemolysis will occur. Indirect complement fixation test: It is used when … Read moreTypes of Complement Fixation Test

Complement Fixation Test- Steps, Advantages and Disadvantages

Complement Fixation Test- Steps, Advantages and Disadvantages

Complement Fixation Test is a classic method for demonstrating the presence of antibody in patient serum. It is based on the principle that antigen-antibody complex fixes the complement. As coupling of complement has no visible effects or changes, it is necessary to use an indicator system consisting of sheep RBC and coated with anti-sheep RBC … Read moreComplement Fixation Test- Steps, Advantages and Disadvantages