Complement Activation- Classical, Alternative and Lectin Pathways

Complement Activation- Classical, Alternative and Lectin Pathways

Activation of complement involves the sequential proteolysis of proteins to generate enzyme complexes with proteolytic activity.  Proteolytic cascades allow tremendous amplification because each enzyme molecule activated at one step can generate multiple activated enzyme molecules at the next step. The … Read more

Classical Pathway of Complement Activation

Classical Pathway of Complement Activation

The classical pathway is a chain of events in which complement components react in specific sequences as a cascade resulting in cell lysis. It is activated by antibody bound to antigen (Antigen-Antibody complex) but never by native or free antibody. … Read more