Chlamydia trachomatis- An Overview

Chlamydia trachomatis

Habitat of Chlamydia trachomatis It is an obligate intracellular human pathogens. Humans are the only natural host. It cannot survive outside of a eukaryotic host. Chlamydia trachomatis is transmitted by oral, vaginal or anal sex, and can also be transmitted from mother to newborn during a vaginal delivery. They can cause discharge from the penis, pain and burning during urination, infection or inflammation in the ducts of testicles, and tenderness or pain in the testicles. Morphology of Chlamydia trachomatis It … Read more

Pathogenesis and Clinical Manifestations of Chlamydia trachomatis

Pathogenesis of Chlamydia trachomatis Chlamydia are acquired by direct contact with mucous membranes or abraded skin, that is, by sexual contact or by direct inoculation into the eye in the case of trachoma or neonatal conjunctivitis. Two forms of the organism are needed for infection and disease to occur: the infectious, extracellular form called an elementary body (EB) and the noninfectious but metabolically active intracellular form called a reticulate body (RB). Receptors for EBs are primarily restricted to nonciliated columnar, … Read more

Laboratory Diagnosis, Treatment, Prevention and Control of Chlamydia trachomatis

Laboratory Diagnosis of Chlamydia trachomatis Specimen Urethral discharge, cervix swab, rectum, oropharynx, and conjunctiva swab are the frequently collected specimens. In addition, other specimens such as, blood, urine, respiratory secretions, sputum, lung, and other tissues are collected and examined. Pus from bubo is also useful for diagnosis of LGV. Microscopy Demonstration of chlamydial inclusion bodies stained by Giemsa, Castaneda, Machiavello, Gimenez stains or Lugol’s iodine. C. trachomatis infections of conjunctiva, urethra, and cervix are diagnosed by demonstration of typical reniform … Read more

Biochemical Test of Bacteria

Biochemical Test of Bacteria

Biochemical reactions are very important in the identification of bacterial isolates and in the identification of different bacterial species. These tests depend on the presence of certain enzymes, such as catalase, oxidase, urease, gelatinase, etc., produced by the bacteria. Different bacteria produce varying spectra of enzymes. For example, some enzymes are necessary for the bacterium’s individual metabolism, and some facilitate the bacterium’s ability to compete with other bacteria or establish an infection. Tests that measure single bacterial enzymes are simple, … Read more

Biochemical Test of Chlamydia trachomatis

Biochemical Test of Chlamydia trachomatis

Some of the characteristics are: Basic Characteristics Properties (Chlamydia trachomatis) Organism Type Obligate intracellular organism that parasitize and multiply in the cytoplasm of eukaryotic cells within membrane bound vacuoles, termed inclusions, by a unique developmental cycle. ATP/ADP Transport System Negative (-ve) Body Types Elementary and Reticulate Flagella Absent Gram Staining Gram-negative Genus Specific Antigen Positive (+ve) Motility Negative (-ve) Projections on Surface Positive (+ve) Shape Coccoid; 0.2-1.5 Um diameter Amino Acid Utilization Arginine Negative (-ve) Cysteine Negative (-ve) Glutamine Variable … Read more

Habitat and Morphology of Chlamydia trachomatis

Habitat of Chlamydia trachomatis It is an obligate intracellular human pathogens. Humans are the only natural host. It cannot survive outside of a eukaryotic host. Chlamydia trachomatis is transmitted by oral, vaginal or anal sex, and can also be transmitted from mother to newborn during a vaginal delivery. They can cause discharge from the penis, pain and burning during urination, infection or inflammation in the ducts of testicles, and tenderness or pain in the testicles. Morphology of Chlamydia trachomatis It … Read more