Beta-Lactamase and Ambler classification

Beta-Lactamase and Ambler classification

β-lactamase enzymes are capable of hydrolysing the β-lactam rings (the active site) of β-lactam antibiotics; thereby deactivating their antibacterial properties. It is observed in both gram-positive and gram-negative bacteria. They are plasmid coded, and transferred from one bacterium to other mostly by conjugation, (except in Staphylococcus aureus where they are transferred by transduction). Beta lactamases can be classified in two …

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