Coomb’s Test- Direct and Indirect Coomb’s Test

Result Interpretation of Coomb's Test

Coomb’s test is a direct agglutination reaction, more commonly known as antiglobulin test. It was discovered by Coombs, Mourant and Race in 1945 originally for the detection of incomplete anti-Rh antibodies. In the test, incomplete antibodies do not agglutinate erythrocytes. … Read more

Types of Agglutination Reactions

Antiglobulin (Coombs) test

Agglutination reactions can be broadly divided into three groups: Active/Direct agglutination Passive agglutination Hemagglutination 1. Active agglutination Agglutination reactions where the antigens are found naturally on a particle are known as direct agglutination. In active agglutination, direct agglutination of particulate … Read more

Agglutination – definition, reactions and applications

Agglutination- Introduction and Applications

Agglutination definition Agglutination is an antigen-antibody reaction in which a particulate antigen combines with its antibody in the presence of electrolytes at a specified temperature and pH resulting in the formation of visible clumping of particles. It occurs optimally when … Read more